The TRIPS Council will submit the agreement to a general review after five years; however, it also has the power to review it at any time in light of new relevant developments that may warrant an amendment and amendment (Article 71). All WTO agreements (with the exception of some multi-lateral agreements) apply to all WTO members. Members accepted all agreements as one package with one signature, which made them one company in the jargon. The 2002 Doha Declaration confirmed that the TRIPS agreement should not prevent members from taking the necessary steps to protect public health. Despite this recognition, less developed countries have argued that flexible TRIPS provisions, such as mandatory licensing, are almost impossible to obtain. The least developed countries, in particular, have made their young domestic manufacturing and technological industries proof of the infallible policy. General transitional periods apply to the original members of the WTO, i.e. governments that were members on 1 January 1995. Since the creation of the WTO, a number of countries have joined. These countries have generally agreed in their accession agreements (their accession protocols) to implement the TRIPS agreement from the date of their formal WTO membership, without a transition period being implemented. All members, including those benefiting from longer transitional periods, had to comply, from 1 January 1996, with the obligations of mobilization (equal treatment of foreign and domestic persons and enterprises, Article 3) and of the most favoured nation (non-discrimination between foreign persons and companies, Article 4).

Since the TRIPS agreement came into force, it has been criticized by developing countries, scientists and non-governmental organizations. While some of this criticism is generally opposed to the WTO, many proponents of trade liberalization also view TRIPS policy as a bad policy. The effects of the concentration of WEALTH of TRIPS (money from people in developing countries for copyright and patent holders in industrialized countries) and the imposition of artificial shortages on citizens of countries that would otherwise have had weaker intellectual property laws are common bases for such criticisms. Other critics have focused on the inability of trips trips to accelerate the flow of investment and technology to low-income countries, a benefit that WTO members achieved prior to the creation of the agreement.